Everything worth knowing, nothing that isn't.
Format numbers as E.164
International delivery depends on fully-qualified numbers: a leading plus, the country code, then the subscriber number, with no spaces or leading zeros. Validate and normalise your list first — an HLR lookup also tells you the current operator and whether the number is reachable. See /answers/what-is-e164 and /products/hlr-lookup.
Route quality decides delivery
The same message can deliver flawlessly to one country and vanish in another depending on whether your provider holds a direct A2P agreement there. Confirm the route to each priority country is direct, not a grey route. See /answers/what-is-grey-route-sms and /answers/how-to-choose-sms-provider.
Sender IDs and content rules differ by market
Many countries require alphanumeric sender IDs to be pre-registered, and some restrict content or mandate local templates. Lead times and rules vary, so plan per-market. See /answers/how-to-register-sender-id and the /regulations guides.
Pricing varies by destination
Each country's operator sets its own A2P termination fee, so per-message cost can vary by an order of magnitude between destinations. Compare cost per delivered message, not headline rate. See /answers/sms-pricing-explained.